On April 15, the functional genomics research of depression in kunming animal institute made progress, and preliminarily identified the target genes regulated by genetic variation, which will help to analyze the genetic mechanism and pathogenesis of depression, thus providing a new potential target for the treatment of depression.

Using the method of functional genomics, luo xiongjian of kunming institute of zoology systematically studied the regulatory mechanism of genetic variation in depression risk. Combining chromatin immunoprecipitation sequencing and location matrix data, 34 genetic variants of depression risk that interrupt the binding of transcription factors were identified. A series of functional experiments (including reporter assay, allele-specific expression analysis, and crispr-cas9-mediated gene editing) were conducted to systematically investigate the potential mechanisms by which these functional genetic variants regulate target genes.Further loci analysis of expressed quantitative traits revealed potential target genes regulated by these functional genetic variations.

The risk of depression from GWAS identification to the research identified in the genetic variation (or potentially pathogenic) functional consequences of genetic variation, prompt genetic variation may be affected by these functional risk with transcription factors, in turn, control the risk of depression gene expression, and identify the target genes is regulated by the genetic variation in these functions. Further research on these functional genetic variants (or pathogenicity) and their target genes will help to elucidate the genetic mechanism and pathogenicity of depression, thus providing a new potential target for the treatment of depression.

Epidemiological studies have found that depression affects about 6 percent of adults, and the suicide rate among depressed people is about 20 times higher. High prevalence and mortality rates make depression a major global burden of disease and cause of disability. A large number of studies have shown that depression can be caused by genetic and environmental factors, and the heritability of depression is about 37%, indicating that genetic factors play a role in the occurrence of depression.

Source: https://baijiahao.baidu.com

Time: 2020.04.15