The new coronavirus is very virulent and difficult to coexist with the host for a long time

It has been found that all the above viruses can be divided into four categories according to a special sequence in the first site, each of which has a similar virulence and the special sequence is almost identical.The first category includes the Middle East respiratory syndrome (MERS) virus and the HKU4 virus in bats, which are the most virulent. SARS virus and new coronavirus belong to the second category, and their virulence is second only to the former. The third category includes human coronavirus such as OC43 and HKU1, which are less virulent.All coronavirons other than the first three fall into the fourth category.

According to the existing data, there are few virus species and host species found in the first and second types, which are probably due to the strong virulence, the virus is difficult to coexist with the host for a long time and gradually extinct, while the third type of virus is weak, and it is possible to acquire host adaptability after long-term evolution and achieve long-term existence in the host. "Bar code" sequence is conservative, not easy to mutate, new coronavirus is unlikely to evolve into the third class of viruses.According to its classification and virulence, as long as mankind takes effective control measures, it will probably go extinct.

Viruses can be classified into tubes to be wary of potential threats

The classification of coronavirus based on "bar code" can easily and quickly estimate the virulence of unknown viruses, lay a foundation for virus classification management, and make future prevention and control more targeted. Several coronavirus species, such as HKU4 and HKU5 carried by bats and HKU31 carried by hedgehogs, fall into the first category and, although they have not yet been reported to infect humans, should still be a major surveillance and research target.

Recently, it has been reported that there are coronaviruses in pangolins that are highly similar to the new coronaviruses, although pangolins are not necessarily the intermediate host of the new coronaviruses, because the two viruses are not the same in terms of variable translation typing, and the genome of pangolins coronaviruses does not have the unique Furin restriction sites of the new coronaviruses. However, humans still need to pay attention to the potential threat of the virus, which has been found to belong to the second type of virus, and its virulence is estimated to be on the same level as SARS and the new coronavirus.

Be on high alert for virulent class I and ii viruses that have been detected and may appear in the future. In contrast, the third type of virus has many species and a wide range of hosts, and may periodically occur in small outbreaks, but the virulence is weak and the threat is small.

Time: 2020.03.10.

Source: https://news.china.com